Histamine Intolerance, How I’m Reducing My Rashes And Hives

Char's bare leg full of itchy bumps. Title reads: How I'm managing histamine intolerance. Eliminating the itching, rashes and hives.

Have you been experiencing itching, rashes or hives since changing your diet? Have you had no luck in identifying an allergen or trigger despite elimination diets and eating clean? If you have recently switched to a low carb diet, it is very possible that you are experiencing an allergic reaction, though you might not be allergic to individual items, it might be a little more complicated than that.

Something I recently discovered, which surprised me, is that people can be histamine intolerant. Many people aren't aware that histamine is present on all our food, even the fresh, natural produce and meat you buy from your local supermarket. Not only can ingredients contain histamine, but some liberate histamine already present in the body.

Histamine is a compound that is produced by our bodies as well as by the bacteria that grows on our food as it ages. It is released when there is inflammation or an allergen introduced to the body. It has healing properties, but some people are sensitive to it. Anybody who has ever suffered from seasonal allergies will know what that feels like.

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Histamine And Low Carb Diets

I have very recently discovered that histamine issues are quite likely to arise when people switch to a low carb diet. The reason being that people who switch to the low carb way of life will tend to introduce many high histamine foods into their diet without realising it. The problem is that a small fraction of us probably lack the enzymes (DAO) needed to manage and eliminate histamine build-up in the body. This isn't a problem for most people, our bodies are designed to produce and eliminate histamine on a daily basis, but for some of us this just isn't happening correctly.

Foods that we are encouraged to eat for gut health, like probiotics and fermented foods are extremely high in histamine. As are many fruit and vegetables. Meat and fish produce histamine at a very high rate as the meats age after slaughter, sometimes being stored for weeks before they arrive in our homes.

Tinned fish and vegetables are super convenient for those of us who no longer rely on quick sandwiches, but tinned food is aged and high in histamine. And if you're trying to increase your fat intake like I did when trying to reach ketosis, then you're probably going to be snacking on salami, avocados, cheese, nuts, seeds - all of which are high in histamine too!

As you can already see, making the switch to low carb is going to be tough for somebody who is histamine intolerant. The problem is that most people are unaware of the condition and many won't know they have an issue with histamine elimination until symptoms appear. The good thing is that you can reduce the histamine levels in your body and help your body to manage histamine better, if you know what to do and are prepared.

My Histamine Story

The month I first started the ketogenic diet in order to reduce my symptoms of ME/CFS was the month I also started itching. I initially suspected the "keto rash" which I looked into and eventually realised wasn't my problem. You can read about that investigation and how you can check if you have keto rash here.

I went through a few months of itching before somebody mentioned histamine intolerance. I had never heard of it, but they said my symptoms sounded similar to what they had experienced.

Initial rash, Histamine Intolerance, Chronically Hopeful

Initial Rash

My journey started with itching, no rashes, no visible signs at all on my skin, just itching all over my body. It gradually increased in intensity and eventually a patch appeared on my one leg. Just a small area of red bumpy skin which doctors told me was eczema. It was super itchy and slowly increased in size over a couple of months despite using cortisone creams and antihistamines prescribed by my doctor.

My first big scare came when I was sitting by the window with my legs in the sun and suddenly my whole body started burning up and turning red. Not only that, but I had a burning itch all over my entire body, like every pore had just excreted acid and it was stinging and itching all at once.

I stripped down and hopped in a cold bath where I stayed for over an hour before it calmed down. My sister ran to the shops to get me some antihistamines while I was in there.

Tummy Rash, Histamine Intolerance, Chronically Hopeful

Tummy Rash

This happened a couple of times over the next few weeks. It seemed to be triggered by heat. Not only would I get these red rashes and the burning itch, but my joints would swell and burn up too. My knees, elbows and knuckles mainly. Ice packs and cold wet towels on my skin help to bring things back to normal.

Daily Hives On Legs, Histamine Intolerance, Chronically Hopeful

Daily Hives On Legs

Eventually the hives came on and just didn't go away anymore. I'd wake up with them every day and they'd flare up terribly after every meal. Evenings were bad, the itching was becoming unbearable, it was keeping me up at night.

Red Spots All Over, Histamine Intolerance, Chronically Hopeful

Red Spots All Over

Then the red spots that had started out on my lower legs and then upper arms, spread all over my whole body until only my face was free of these itchy, red bumps. It eventually got so bad that the hives were just constantly flaring for days on end, without any relief. My legs were so bumpy and itchy, I couldn't stop scratching, I couldn't sit still, I couldn't rest.

I'd describe the constant itch as mosquito bites on sunburn and then, when the hives flared after a meal, it was like being stabbed by thousands of needles all over my body and the itching became more intense too. I was in tears of frustration on more than one occasion!

Hives Flaring On Legs, Histamine Intolerance, Chronically Hopeful

Hives Flaring On Legs

Not only was the itching driving me to desperation, but I had been scratching so much that my arms were aching and I was exhausted. Having ME/CFS means that any exertion, even scratching myself, causes an increase in all my other symptoms too. This allergic reaction was draining me of the very little energy I had. I'd wake up with cramps in my hands from scratching at night and sometimes simply from itching so much. My legs were bruised all over and it was starting to hurt.

Bruising On My Legs, Histamine Intolerance, Chronically Hopeful

Bruising On My Legs

How I Got Rid Of The Hives And Rashes

I have joined many support groups online and read as much as I can in my condition, a low histamine diet has helped a little initially, but the only thing that has stopped the hives completely has been a combination of fasting and antihistamines.

I was initially on Fexofenadine, but when this was no longer making a difference and my condition was only getting worse, my doctor prescribed Ranitidine to take alongside the Fexofenadine.

Rash On My Face, Histamine Intolerance, Chronically Hopeful

Rash On My Face

At this point the hives had become constant and the rash had moved onto my face. I had red bumpy skin under my eyes and on my cheeks and the area below my eyes was swollen, burning up and very itchy! I spoke to my doctor again and she substituted the Fexofenadine, giving me Atarax instead. At this point I was hardly functioning anymore, scratching was taking up all my energy and I couldn't even think properly anymore. The itch was consuming and I was utterly exhausted.

Somebody suggested fasting for a few days and although I had read that some people flared even more with fasting, I thought it was worth a try if it could possibly help. I initially thought I'd fast for 48 hours, but after 24 hours I was already feeling relief, so I ate a meal and then fasted for another day. After three days of fasting like this, eating only one meal after a 23 hour fast, the hives were gone!

I have been eating one meal a day (OMAD) since the first of September, so it's been 18 days now, and although I'm still itching, it is way less intense and I can function again. No sign of hives since, except when I bath. I'm not sure if it's to do with the water temperature or chemicals in the soap or shampoo, or even if its simply because of the extra exertion, but the only time I get hives now is when I bathe.

Even the red spots I have all over my body are no longer inflamed, raised and burning, but are calming down and starting to disappear.

I have started having a small snack in the evenings, mainly meat and fat,with thyme, no vegetables. So far so good. I also introduced apples and sweet potatoes into my diet when I started the OMAD because they contain things that help to reduce histamine levels in the body. This does mean that I'm likely out of ketosis again, but it's helping my body with the histamine overload, so I'm okay with that.

The Histamine Basin

A great way to look at histamine in the body is to imagine your body as a basin. All basins should have an overflow drain so that if the basin gets too full, then it won't overflow because the overflow drain will drain away the excess, keeping the basin level.

Our bodies should have an overflow drainage system too, it's called DAO, it's an enzyme that helps to remove histamine from the body. For those of us who have histamine intolerance, chances are our overflow drain (DAO) isn't functioning correctly, or it's missing completely. This means that when our histamine levels get too high, there's no overflow pipe to drain away the excess histamine and our basin just overflows all over the place resulting in itching, hives, rashes, runny nose, sore throat or even stomach ache and IBS!

The key is to keep the basin from overflowing. That is why fasting has helped me, by putting food in less frequently, I've given my body time to deal with the histamine it already has. It's as if my basin has a drain block and it's draining super slowly. I can't put anything else in until some of what's already in there drains out.

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My Action Plan

I asked many questions and read many testimonies online and came up with an action plan for myself:

  1. Atarax (Hydroxyzine Hydrochloride), three times a day (upon waking, 6pm, then before bed) and Ranitidine (Ranitidine Hydrochloride), before eating.
  2. Fast for at least 16 hours a day. One meal mid day and then a small snack later, if hungry and not flaring.
  3. Supplements I take daily: 2000-3000mg of vitamin C, 4000mg of MSM, 5000IU of D3 and Quercitin powder with all my meals.
  4. Magnesium flakes or epsom salt in the bath.
  5. Drink lots of water with electrolytes: pink salt or celtic salt, LoSalt for potassium and magnesium. (salt is natural antihistamine, not table salt)
  6. Eat not only low histamine foods, but also reintroduce anti-histamine and anti-inflammatory foods to equip the body to handle the inflammation and histamine already in my system.
  7. Eat no processed, aged, fermented, tinned or pickled food.
  8. Eat only fresh food cooked from scratch. Leftovers are frozen after dinner and eaten immediately after reheating.
  9. Avoid other common allergens like dairy, grains, nuts, eggs, etc. And inflammatory foods like sugar.

Some of the anti-histamine or anti-inflammatory foods I make sure to include daily:

  • Golden milk, once or twice a day (fresh ginger, tumeric, cinnamon, coconut milk, hot water, coconut oil)
  • Fresh thyme in all my meals
  • Some apple or sweet potato
  • Blueberries
  • Fresh garlic
  • Olive oil in all my meals
  • Coconut oil on my skin

For Immediate Relief During A Histamine Reaction:

Here are some things that have helped me during a histamine reaction. I usually start burning and itching all over, it stings quite a bit and my joints get red and swollen and very hot. Heat aggravates it, so you'll need to cool down the affected areas quickly.

  • Lie in a cold bath or lay cold wet towels on the itching skin (avoid warm or hot baths/showers)
  • I moisturise with coconut oil (test on a small area first)
  • Use ice packs for swelling and burning up of the joints
  • Drink lots of water, add salt
  • Take Antihistamine (I prefer Atarax at this point) and Vitamin C
  • Do something relaxing and distracting like watch a calm movie, stress or excitement can trigger histamine release, so you need to stay as calm as possible.

Something else you might want to try is Three Tulsi Holy Basil Tea, I found many people recommending it online, I didn't notice any improvements from it personally, but it's worth a shot if you'd like a hot drink and everything else is a trigger. I had a bad reaction from Chamomile and Rooibos wasn't great either. My histamine release was triggered by heat, so that could have something to do with why I couldn't tolerate hot drinks.

We are all unique, so you will have to rely on trial and error to find which things your body really doesn't like and which items it doesn't react badly to. I hope my list is a helpful starting point for you. I know I was so lost when I first realised what was happening. It is not easy to find all the necessary information and my doctors were not much help either.

Some useful links:

You might also want to look into Mast Cell Activation Disorder (MCAD). Unfortunately this is another condition which is not well understood and quite tricky to manage. There are support groups on Facebook where you will find others who understand. You can share your experience and learn management tips.

Char's bare leg full of itchy bumps. Title reads: How I'm managing histamine intolerance. Eliminating the itching, rashes and hives.

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Have you experienced anything like this?

  • How did you manage it?
  • Do you have any tips or tricks that could be helpful to somebody dealing with such allergic reactions?
  • I'd love to hear from you! Please leave a message in the comments below or contact me privately.

UPDATE ​December 2017

My itching and hives are under control now. I got rid of the hives by fasting for 24hours a day for three days. This means that every 24 hours I'd have a 1hour window in which I would eat my meals according to the above plan. Within 3 days the hives were gone. I continued for almost 2 weeks eating once a day only. Please keep in mind that I am on the ketogenic diet, which keeps me satiated, drinking a lot of water and electrolytes helps too.

After the initial 2 weeks, I started reintroducing a second meal, more of a high fat and protein snack in the evenings as mentioned above, so my fasting window reduced from 24 hours to 16. I did this for most of October, after which my itching had completely gone away and I could start reintroducing some foods again. In small quantities. My itch has only returned, very mildly, since we switched our winter heating on in the house about a week ago. Heat is a trigger for my histamine response, but cold is bad for my chronic pain and muscle shakes caused by ME/CFS, so I'll put up with the slight itch and adjust my meals accordingly to keep it under control.

​UPDATE ​August 2019

There were only a few itchy episodes in the winter of 2017. The whole of 2018 was incident free, except when I ate spinach which seems to give me an instant reaction almost every time I eat it.

2019 has been almost completely incident free, except two reactions which I later realised were caused by a peanut flavoured protein shake I was having for lunch. I rotate through a variety of flavours and only had reactions on the peanut flavour days. Since stopping that shake, I have not had any more reactions.

I continue to eat a low histamine diet most of the time, but am able to enjoy a couple of high histamine foods daily in small doses. I also continue to use quercitin powder sprinkled on one meal a day and at least one serving of olive oil a day. I also still take the salt drinks as supplementing electrolytes is important for Keto. I no longer take antihistamines, except during ​peak pollen season.

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  • Oh my gosh that’s an awful journey! I’m glad you were able to find the cause and begin to treat it. I got itchy after showers, like insanely itchy, but now I take cooler, quick showers and it helps. I eat only meat, fruit, veggies and nuts and have since ’13 (helps my fibro). The itching came about last year. Thankfully the cooler water seems to help. Hoping you can find a good balance. You’re so strong I think I would have just freaked out. Although the year I was diagnosed with fibro I had inexplicable hives. These bodies just kinda do what they want don’t they.??

    • So true! Our bodies just seem to do whatever. Just last night I realised that there are really quite a few symptoms that many of us get which just don’t appear on the symptom lists you find online. Quite bizarre things too!

      Support groups are great for this though, you realise “oh good! I’m not a freak, they all have the same problem too!” Although it’s not nice that others suffer the same issues, it is comforting to know we are not alone in it and others understand. x

      • Very, very true! Social media has set my mind at ease innumerable times with regard to odd symptoms.???

        • Shanu says:

          So basically what u mean is fasting has been a major role to get rid of hives ?
          Im suffering from last September 2019 almost 1 year ! Every day i take anti histhamine tablets i cant see any dfrnce !
          Will try fasting as well now !
          Planning now for homeopathy treatment!

          • It was for me, but everybody is different. I have heard from some that it made things worse, but it’s worth a shot if it could help so I took the risk and it worked for me. I hope you find a solution soon.

  • M. Russell says:

    I am forever appreciative and grateful to you — for sharing your ordeal in detail, the knowledge you have gained along the way, and how you have progressed. Your symptoms and ailments COMPLETELY mirror mine, and I haven’t been able to figure it out. Ive been battling this all too debilitating “condition” since I can remember, have been misdiagnosed year after year, and led down dead-end roads each and every time. Couldn’t understand for the life of me why NO ONE could help me or put this together – it’s been endless docs, allergists, Dermatologists, creams, steroids etc. Recently with the more pronounced heat/sweat reactions I’ve been led down the road of auto-immune specialists, a rheumatologist, etc….nothing. It has been a debilitating, torturous and all consuming battle, and you have changed that for me – simply by selflessly sharing. Specific/detailed information is soo limited on this, and yours is the only one that has FINALLY validated/pieced it all together. THANK YOU

    • Wow, I am so sorry you have been struggling to find help for so long!

      It really is so hard to find information on this. I am glad you have found my story helpful. I hope you have been able to relieve your responses. I’d love to know how you are getting on.

      Wishing you much relief and healing. Hugs

  • Sheryl says:

    The hives’ progression looks super awful!! I get random hives outbreak as well, but usually easily controlled with anti-histamines (I have 4-5 different types at home, depending on situation!). Will re-share this handy guide everywhere!

    • Thanks Sheryl! It was my first time experiencing this last year… 7 months of itching before somebody mentioned this, so I hope to help people before they have to suffer so long. I usually only get seasonal allergies, this was a whole other thing, the usual antihistamines were not touching it. It’s almost 9 months later and I’m still eating low histamine meals, but I can now include some cheaky high histamine items a couple of times a week, spread out, without much reaction if any.

  • Ruthy says:

    Hi I was on keto and also developed a reaction and now is been 8 months with this torment, i decided to do sort of semi vegetarian paleo instead, do you think I could do same fast like you, every 24 hours or should I start slow? I’m taking Zyrtec and Benadryl in between, I don’t have insurance.

    • Hi Ruthy, I’m so sorry you are dealing with this too. It is so frustrating! I would try fasting, maybe start with a 12 hour fast overnight (skip dinner or breakfast) and see how that goes for you. Then 16-18 hours. Then 24 if you can manage it. Make sure to hydrate very well between, add electrolytes to your water so that you don’t feel faint. You could take a few adrenal cocktails throughout the day between glasses of water. If your reactions are triggered or flare up from eating then the fasting should lower your histamine load. I hope you find relief soon.

  • darren Smith says:

    Great article on Histamine. I have a question for you in which the answer will determine whether I pursue histamine help. So 3 months ago I began coughing up mucous in the mornings, major nasal congestion, sore throat, red cheeks with a bit of red rash on bridge of the nose, deep inhale pain upper chest/lower throat area. Have had COVID negative test, ultrasound, x-ray, and CT amongst others all negative. My diet is primarily paleo based. So, the funny thing is it doesn’t seem to matter if I eat at all, for example I wake up today and don’t have any food, outside of the normal coughing up phlegm, my nose id completely clogged and my airways congested, nasal breathing is good when sleeping but chest congestion gets worse when upright it is the opposite. So the question I have on Histamine is could my symptoms be a histamine issue due to the fact that they are still there even after not eating for 16 -20 hours, in other words, food doesn’t trigger,m they are just always there! I am believing I have this narrowed down to histamine and/or silent reflux. Thanx! DarrenHello

    • Hi Darren, I cannot say if what you have is histamine or not, but yes, histamine is not only triggered or released in response to food, so you can have histamine build up for any number of reasons. Seasonal allergies, chemical intolerances, allergies to cleaning products, mold sensitivity, etc. It is a possibility. Look into Histamine Intolerance and Mast Cell Activation Disorder/Syndrome (MCAD/MCAS) for more information on this and to see if it resonates with what you’re experiencing. I hope you find your answers soon.

  • Ben Morris says:

    I have had the same as you for around 17 years. I’ve been to doctors and dermatologists and had have to transferred to specialists in London but none could ever find the problem. I have been eliminating food and drink for years trying to find the root cause myself. I eventually, after years of horrendous skin issues, think it is down to histamine intolerance. I would suggest to anyone who has the same issue to consume a low histamine diet. I would also totally suggest taking an antihistamine pill everyday. Also a multivitamin and importantly a separate vitamin pill of magnesium and B6. The antihistamine will obviously lower histamine, the multivitamins will help in general especially with vitamin C and the magnesium and B6 helps production of the DOA enzyme which combats the amount of antihistamine in your body. These simple vitamins have changed life so much and I’m happy again after years and years of being depressed with my skin. I hope anyone reading this has the same results.

    • Thank you for sharing your experience. I am so glad you have had some relief, that is a very long time to go without answers. I am taking the same things you mentioned, except B6 but mine is under control now so I think I’m okay in that regard. Thank you for sharing, I’m sure it will help others.

  • Robin says:

    Thank you so very much for all of this information! I was awake last night with itching/rash again. Mine sounds just like your episodes. I’ve started implementing some of your recommendations. Im see improvement already. Many thanks!!!

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